Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) Standard Curve.)
Human Transforming Growth Factor beta-1-Induced Transcript 1 Protein (TGFB1I1) ELISA Kit | TGFB1I1 elisa kit
Human Transforming Growth Factor beta-1-Induced Transcript 1 Protein (TGFB1I1) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1) Standard Curve.)
Background: TGFB1I1 is a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. TGFB1I1 is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for TGFB1I1.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Uniprot Description
Hic-5: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: extracellular matrix; nuclear matrix; cytoskeleton; focal adhesion; cytoplasm; intracellular
Molecular Function: protein binding; Roundabout binding; androgen receptor binding; zinc ion binding; transcription coactivator activity
Biological Process: transcription from RNA polymerase II promoter; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; Wnt receptor signaling pathway; cell fate commitment; epithelial cell differentiation; response to heat; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; ubiquitin-dependent SMAD protein catabolic process; negative regulation of fat cell differentiation; cell adhesion; negative regulation of transforming growth factor beta receptor signaling pathway
Research Articles on TGFB1I1
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Product Notes
The Human TGFB1I1 tgfb1i1 (Catalog #AAA9714174) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714174 ELISA Kit recognizes Human TGFB1I1. It is sometimes possible for the material contained within the vial of "Transforming Growth Factor beta-1-Induced Transcript 1 Protein (TGFB1I1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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