Human Thrombin Activatable Fibrinolysis Inhibitor (TAFI) ELISA Kit | TAFI elisa kit

Human Thrombin Activatable Fibrinolysis Inhibitor (TAFI) ELISA Kit

Cat. Num. AAA453982

• Gene Names: CPB2; CPU; PCPB; TAFI
• Reactivity: Human
• Synonyms: Thrombin Activatable Fibrinolysis Inhibitor (TAFI); Human Thrombin Activatable Fibrinolysis Inhibitor (TAFI) ELISA Kit; CPB2; CPU; PCPB; Carboxypeptidase B2; Plasma Carboxypeptidase B; Carboxypeptidase U; TAFI elisa kit

• Reactivity: Human
• Sequence Length: 386

• Samples: Plasma.
• Assay Type: Sandwich
• Detection Range: 1.56-100ng/mL
• Sensitivity: 0.67ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 513126877
• NCBI GeneID: 1361
• NCBI Accession #: NP_001265470.1
• NCBI GenBank Nucleotide #: NM_001278541.1
• UniProt Accession #: Q96IY4; Q15114; Q5T9K1; Q5T9K2; Q9P2Y6; A8K464
• Molecular Weight: 40,922 Da
• NCBI Official Full Name: carboxypeptidase B2 isoform 2 preproprotein
• NCBI Official Synonym Full Names: carboxypeptidase B2
• NCBI Official Symbol: CPB2
• NCBI Official Synonym Symbols: CPU; PCPB; TAFI
• NCBI Protein Information: carboxypeptidase B2
• UniProt Protein Name: Carboxypeptidase B2
• UniProt Gene Name: CPB2
• UniProt Synonym Gene Names: CPU; pCPB; TAFI

NCBI Description

Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.