Human TAO Kinase 3 (TAOK3) ELISA Kit | TAOK3 elisa kit
Human TAO Kinase 3 (TAOK3) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TAO3: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress- activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Protein type: Protein kinase, STE; EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; TAO subfamily
Cellular Component: cytoplasm; intracellular
Molecular Function: transferase activity; protein serine/threonine kinase activity; MAP kinase kinase kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of JNK activity; negative regulation of JNK cascade; activation of MAPKK activity; protein amino acid autophosphorylation; mitotic cell cycle G2/M transition DNA damage checkpoint; MAPKKK cascade; response to stress; positive regulation of JNK cascade; DNA repair; response to DNA damage stimulus; protein amino acid phosphorylation; phosphorylation; positive regulation of stress-activated MAPK cascade