Human SPINK1 ELISA Kit | SPINK1 elisa kit

Human SPINK1 ELISA Kit

Cat. Num. AAA824791

• Gene Names: SPINK1; TCP; PCTT; PSTI; TATI; Spink3
• Reactivity: Human
• Applications: ELISA
• Synonyms: SPINK1; Human SPINK1 ELISA Kit; PSTI; Pancreatic secretory trypsin inhibitor; Serine protease inhibitor Kazal-type 1; Tumor-associated trypsin inhibitor; TATI; SPINK1 elisa kit

• Reactivity: Human
• Sequence Length: 79

• Applicable Applications for SPINK1 elisa kit: Sandwich ELISA (SE)
• Samples: Cell Culture Supernatants, Serum, Plasma
• Assay Type: Sandwich
• Detection Range: 156 pg/ml - 10000 pg/ml
• Sensitivity: 10 pg/ml
• Detection Method: Colorimetric
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for SPINK1 elisa kit

Sandwich ELISA for quantitative detection of Human SPINK1 concentrations.

NCBI and Uniprot Product Information

• NCBI GI #: 45505132
• NCBI GeneID: 6690
• NCBI Accession #: NP_003113.2
• NCBI GenBank Nucleotide #: NM_003122.4
• UniProt Accession #: P00995
• Molecular Weight: 8,507 Da
• NCBI Official Full Name: pancreatic secretory trypsin inhibitor
• NCBI Official Synonym Full Names: serine peptidase inhibitor, Kazal type 1
• NCBI Official Symbol: SPINK1
• NCBI Official Synonym Symbols: TCP; PCTT; PSTI; TATI; Spink3
• NCBI Protein Information: pancreatic secretory trypsin inhibitor; tumor-associated trypsin inhibitor; serine protease inhibitor, Kazal type 1
• UniProt Protein Name: Pancreatic secretory trypsin inhibitor
• Protein Family: Serine protease inhibitor
• UniProt Gene Name: SPINK1
• UniProt Synonym Gene Names: PSTI; TATI
• UniProt Entry Name: ISK1_HUMAN

NCBI Description

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

Uniprot Description

SPINK1: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT). A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP). TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: extracellular space

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; endopeptidase inhibitor activity

Biological Process: negative regulation of peptidyl-tyrosine phosphorylation; regulation of acrosome reaction

Disease: Tropical Calcific Pancreatitis; Pancreatitis, Hereditary