Human Secretogranin V (SCG5) ELISA Kit | SCG5 elisa kit

Human Secretogranin V (SCG5) ELISA Kit

Cat. Num. AAA452668

• Gene Names: SCG5; 7B2; SgV; P7B2; SGNE1
• Reactivity: Human
• Synonyms: Secretogranin V (SCG5); Human Secretogranin V (SCG5) ELISA Kit; SCGV; P7B2; SGNE1; SgV; 7B2 Protein; Neuroendocrine protein 7B2; Prohormone Convertase Chaperone; Pituitary polypeptide; Secretory granule endocrine protein I; SCG5 elisa kit

• Reactivity: Human
• Sequence Length: 212

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 15.625-1000pg/mL
• Sensitivity: 5.5pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 221139785
• NCBI GeneID: 6447
• NCBI Accession #: NP_001138229.1
• NCBI GenBank Nucleotide #: NM_001144757.2
• UniProt Accession #: P05408; P01164; Q6FHD0; Q9BS38
• Molecular Weight: 23,659 Da
• NCBI Official Full Name: neuroendocrine protein 7B2 isoform 1
• NCBI Official Synonym Full Names: secretogranin V
• NCBI Official Symbol: SCG5
• NCBI Official Synonym Symbols: 7B2; SgV; P7B2; SGNE1
• NCBI Protein Information: neuroendocrine protein 7B2
• UniProt Protein Name: Neuroendocrine protein 7B2
• Protein Family: Neuroendocrine protein
• UniProt Gene Name: SCG5
• UniProt Synonym Gene Names: SGNE1

NCBI Description

This gene encodes a secreted chaperone protein that prevents the aggregation of other secreted proteins, including proteins that are associated with neurodegenerative and metabolic disease. The encoded protein may be best known for its role in the trafficking and activation of prohormone convertase PC2 (encoded by Gene ID: 5126). Phosphorylation of the encoded protein has been shown to have an inhibitory effect on its chaperone function. [provided by RefSeq, Jul 2016]

Uniprot Description

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.