Structure
BOC-D-FMK, Inhibitor
BOC-D-FMK
Purity
>98% (HPLC)
Synonyms
BOC-D-FMK; Pentanoic acid; 3- [ [ (1; 1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-; methyl ester; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=125mg/mL
Target
Caspase
Receptor
Caspase
Chemical Name
Pentanoic acid, 3-[[(1, 1-dimethylethoxy)carbonyl]amino]-5-fluoro-4-oxo-, methyl ester
SMILES
CC(C)(C)OC(=O)NC(CC(=O)OC)C(=O)CF
Molecular Formula
C11H18FNO5
CAS Number
634911-80-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BOC-D-FMK, inhibitor
BOC-D-FMK is a cell-permeable, irreversible, broad spectrum caspase inhibitor, inhibits apoptosis stimulated by TNF-alpha with IC50 of 39uM; inhibits TNFalpha-stimulated reactive oxygen species (ROS) generation, prevents genistein-induced apoptosis of p815 cells at 50uM; shows neuroprotective effects on spinal motoneurons (MNs) after root avulsion in neonatal rats, suppresses polyethylene particle-induced osteolysis in mice.
References
1. Cowburn AS, et al. Blood. 2005 Apr 1; 105 (7):2970-2.
2. Yee SB, et al. Exp Mol Med. 2006 Dec 31; 38 (6):634-42.
3. Chan YM, et al. Exp Neurol. 2003 Jun; 181 (2):190-203.
4. Landgraeber S, et al. Apoptosis. 2009 Feb; 14 (2):173-81.
2. Yee SB, et al. Exp Mol Med. 2006 Dec 31; 38 (6):634-42.
3. Chan YM, et al. Exp Neurol. 2003 Jun; 181 (2):190-203.
4. Landgraeber S, et al. Apoptosis. 2009 Feb; 14 (2):173-81.
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Product Notes
The BOC-D-FMK (Catalog #AAA3605398) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BOC-D-FMK, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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