Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human S100 calcium binding protein A14 (S100A14) Standard Curve.)
Human S100 calcium Binding Protein A14 (S100A14) ELISA Kit | S100A14 elisa kit
Human S100 calcium Binding Protein A14 (S100A14) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human S100 calcium binding protein A14 (S100A14) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human S100 calcium binding protein A14 (S100A14) Standard Curve.)
Background: S100A14 is a member of a subfamily of proteins related by Ca(2+)-binding motifs to the EF-hand Ca(2+)-binding protein superfamily.Using a proteomics approach to identify genes upregulated in breast cancer, followed by database analysis and PCR of a breast carcinoma cell line, Adam et al. (2003) cloned S100A14, which they called BCMP84. BCMP84 expression in normal tissue was restricted to stratified squamous epithelium of skin, cervix, and tonsil. Weak staining was seen in normal breast ductal tissue, but strong immunoreactivity was detected in 10 of 58 (17%) breast cancer tissues. BCMP84 was expressed in the plasma membrane of transiently transfected breast carcinoma cells.By fluorescence in situ hybridization, Pietas et al. (2002) mapped the S100A14 gene to chromosome 1q21 in a cluster with at least 15 other S100 genes.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Uniprot Description
S100A14: a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: microtubule cytoskeleton; nucleoplasm; perinuclear region of cytoplasm; cytoplasm; plasma membrane; cell junction
Molecular Function: chemokine receptor binding; calcium ion binding
Biological Process: calcium ion homeostasis; apoptosis; defense response to bacterium; response to lipopolysaccharide; toll-like receptor 4 signaling pathway
Research Articles on S100A14
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Product Notes
The Human S100A14 s100a14 (Catalog #AAA9714433) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9714433 ELISA Kit recognizes Human S100A14. It is sometimes possible for the material contained within the vial of "S100 calcium Binding Protein A14 (S100A14), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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