Human Rho related GTP binding protein RhoC (RHOC) ELISA Kit | RHOC elisa kit
Human Rho related GTP binding protein RhoC (RHOC) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.
Protein type: G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein; G protein, monomeric
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component: plasma membrane; cytosol; nucleus; cleavage furrow
Molecular Function: signal transducer activity; protein binding; GTP binding
Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; small GTPase mediated signal transduction; cytokinesis
Research Articles on RHOC
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Product Notes
The Human RHOC rhoc (Catalog #AAA7247411) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7247411 ELISA Kit recognizes Human RHOC. It is sometimes possible for the material contained within the vial of "Rho related GTP binding protein RhoC (RHOC), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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