Rabbit RHOC Polyclonal Antibody | anti-RHOC antibody

RHOC Polyclonal Antibody

Cat. Num. AAA2528402

• Gene Names: RHOC; H9; ARH9; ARHC; RHOH9
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Antigen affinity purification
• Synonyms: RHOC; Polyclonal Antibody; RHOC Polyclonal Antibody; H9; ARH9; ARHC; RHOH9; anti-RHOC antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 193

• Applicable Applications for anti-RHOC antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Synthetic peptide of human RHOC
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Human fetal brain tissue using RHOC Polyclonal Antibody at dilution of 1:300)

Related Product Information for anti-RHOC antibody

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

NCBI and Uniprot Product Information

• NCBI GI #: 111494251
• NCBI GeneID: 389
• NCBI Accession #: NP_001036144.1
• NCBI GenBank Nucleotide #: NM_001042679.1
• Molecular Weight: 22,006 Da
• NCBI Official Full Name: rho-related GTP-binding protein RhoC
• NCBI Official Synonym Full Names: ras homolog family member C
• NCBI Official Symbol: RHOC
• NCBI Official Synonym Symbols: H9; ARH9; ARHC; RHOH9
• NCBI Protein Information: rho-related GTP-binding protein RhoC; RAS-related homolog 9; oncogene RHO H9; ras homolog gene family, member C; rho cDNA clone 9; rhoC GTPase; small GTP binding protein RhoC
• UniProt Protein Name: Rho-related GTP-binding protein RhoC
• Protein Family: Rho-related GTP-binding protein
• UniProt Gene Name: RHOC
• UniProt Synonym Gene Names: ARH9; ARHC; h9
• UniProt Entry Name: RHOC_HUMAN

NCBI Description

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein, monomeric; G protein

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: plasma membrane; nucleus; cytosol; cleavage furrow

Molecular Function: protein binding; signal transducer activity; GTP binding

Biological Process: axon guidance; regulation of small GTPase mediated signal transduction; apical junction assembly; positive regulation of I-kappaB kinase/NF-kappaB cascade; small GTPase mediated signal transduction; cytokinesis