Human Ras GTPase Activating Protein 1 (RASA1) ELISA Kit | RASA1 elisa kit
Human Ras GTPase Activating Protein 1 (RASA1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
Uniprot Description
RASA1: a GTPase activator for normal RAS p21 but not its oncogenic counterpart, converting it to the putatively inactive GDP-bound state. Acting as a suppressor of RAS function, it enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Two alternatively spliced isoforms have been described.
Protein type: Oncoprotein; Motility/polarity/chemotaxis; GAPs; GAPs, Ras
Chromosomal Location of Human Ortholog: 5q13.3
Cellular Component: ruffle; cytoplasm; cytosol
Molecular Function: GTPase binding; protein binding; glycoprotein binding; potassium channel inhibitor activity; receptor binding
Biological Process: axon guidance; negative regulation of cell adhesion; signal transduction; negative regulation of cell-matrix adhesion; regulation of cell shape; regulation of actin filament polymerization; embryonic development; cytokinesis after mitosis; regulation of RNA metabolic process; ephrin receptor signaling pathway; blood vessel morphogenesis; negative regulation of Ras protein signal transduction; negative regulation of neuron apoptosis; vasculogenesis; vascular endothelial growth factor receptor signaling pathway
Disease: Parkes Weber Syndrome; Capillary Malformation-arteriovenous Malformation; Basal Cell Carcinoma, Susceptibility To, 1
Research Articles on RASA1
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Product Notes
The Human RASA1 rasa1 (Catalog #AAA9312877) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9312877 ELISA Kit recognizes Human RASA1. It is sometimes possible for the material contained within the vial of "Ras GTPase Activating Protein 1 (RASA1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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