Human Pancreas Specific Transcription Factor 1a (PTF1a) ELISA Kit | PTF1a elisa kit
Human Pancreas Specific Transcription Factor 1a (PTF1a) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]
Uniprot Description
PTF1A: Transcriptional activator. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays an important role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Defects in PTF1A are the cause of diabetes mellitus and cerebellar hypoplasia/agenesis (DMCH).
Chromosomal Location of Human Ortholog: 10p12.2
Cellular Component: transcription factor complex; cytoplasm; nucleus
Molecular Function: protein dimerization activity; DNA binding; sequence-specific DNA binding; chromatin binding
Biological Process: retinoic acid receptor signaling pathway; tissue development; embryonic development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; pancreas development; neuron fate commitment; exocrine pancreas development; cerebellum development; positive regulation of transcription from RNA polymerase II promoter; endocrine pancreas development
Disease: Pancreatic And Cerebellar Agenesis; Pancreatic Agenesis 2
Research Articles on PTF1a
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Product Notes
The Human PTF1a ptf1a (Catalog #AAA9309090) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9309090 ELISA Kit recognizes Human PTF1a. It is sometimes possible for the material contained within the vial of "Pancreas Specific Transcription Factor 1a (PTF1a), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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