Human NOP10 ribonucleoprotein homolog (yeast) ELISA Kit | NOP10 elisa kit

Human H/ACA ribonucleoprotein complex subunit 3, NOP10 ELISA Kit

Cat. Num. AAA9337821

• Gene Names: NOP10; DKCB1; NOLA3; NOP10P
• Reactivity: Human
• Synonyms: NOP10 ribonucleoprotein homolog (yeast); Human H/ACA ribonucleoprotein complex subunit 3; NOP10 ELISA Kit; Human H/ACA ribonucleoprotein complex subunit 3 (NOP10) ELISA kit; MGC70651; NOLA3; NOP10P; homolog of yeast Nop10p; nucleolar protein family A; member 3; member 3 (H/ACA small nucleolar RNPs) ; NOP10 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 8923942
• NCBI GeneID: 55505
• NCBI Accession #: NP_061118.1
• NCBI GenBank Nucleotide #: NM_018648.3
• UniProt Accession #: Q9NPE3
• Molecular Weight: 7,706 Da
• NCBI Official Full Name: H/ACA ribonucleoprotein complex subunit 3
• NCBI Official Synonym Full Names: NOP10 ribonucleoprotein
• NCBI Official Symbol: NOP10
• NCBI Official Synonym Symbols: DKCB1; NOLA3; NOP10P
• NCBI Protein Information: H/ACA ribonucleoprotein complex subunit 3; nucleolar protein 10; snoRNP protein NOP10; homolog of yeast Nop10p; NOP10 ribonucleoprotein homolog; nucleolar protein family A member 3; nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)
• UniProt Protein Name: H/ACA ribonucleoprotein complex subunit 3
• Protein Family: Ribosome biogenesis protein
• UniProt Gene Name: NOP10
• UniProt Synonym Gene Names: NOLA3
• UniProt Entry Name: NOP10_HUMAN

NCBI Description

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p. [provided by RefSeq, Jul 2008]

Uniprot Description

NOP10: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. Defects in NOP10 are a cause of dyskeratosis congenita autosomal recessive type 1 (DKCB1). A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy. Belongs to the NOP10 family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: 15q14-q15

Cellular Component: Cajal body; small nucleolar ribonucleoprotein complex; nucleolus

Molecular Function: snoRNA binding; protein binding

Biological Process: pseudouridine synthesis; rRNA processing

Disease: Dyskeratosis Congenita, Autosomal Recessive, 1