Human NLRC3/NLR family CARD domain-containing protein 3 ELISA Kit | NLRC3 elisa kit
Human NLRC3/NLR family CARD domain-containing protein 3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Description
NLRC3: May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: cytoplasm
Molecular Function: ATP binding
Biological Process: I-kappaB kinase/NF-kappaB cascade; T cell activation; regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB cascade
Research Articles on NLRC3
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Product Notes
The Human NLRC3 nlrc3 (Catalog #AAA2905040) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2905040 ELISA Kit recognizes Human NLRC3. It is sometimes possible for the material contained within the vial of "NLRC3/NLR family CARD domain-containing protein 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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