Rabbit anti-Human MAPK6 Polyclonal Antibody | anti-MAPK6 antibody

Anti-MAPK6 Antibody, Rabbit Polyclonal

Cat. Num. AAA8101438

• Gene Names: MAPK6; ERK3; PRKM6; p97MAPK; HsT17250
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: MAPK6; Polyclonal Antibody; Anti-MAPK6 Antibody; Rabbit Polyclonal; ERK3/MAPK6 Antibody; Rabbit PAb; Antigen Affinity Purified; mitogen-activated protein kinase 6; Anti-ERK3 Antibody; Anti-HsT17250 Antibody; Anti-p97MAPK Antibody; Anti-PRKM6 Antibody; anti-MAPK6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human MAPK6
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-MAPK6 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human ERK3/MAPK6
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human ERK3/MAPK6, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human MAPK6 in cynomolgus heart with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedd.)

Immunohistochemistry (IHC)

(Immunochemical staining of human MAPK6 in mouse heart with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human MAPK6 in rat heart with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-MAPK6 antibody

MAPK6 (Mitogen-Activated Protein Kinase 6) is a Protein Coding gene. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is most closely related to mitogen-activated protein kinases (MAP kinases). MAPK signaling is a critical pathway in many biological processes. MAPK6 is most highly expressed in liver cancer samples. A divergent lncRNA (long non-coding RNA) of MAPK6, termed lncMAPK6 here, is also overexpressed along with liver tumorigenesis. It was the most highly expressed MAPK component in liver cancer and liver TICs and lncMAPK6 participated in the transcriptional regulation of MAPK6in cis. MAPK6 is widely expressed in the testis, brain, and other tissues. Diseases associated with MAPK6 include Pulmonary Immaturity and Breast Mucoepidermoid Carcinoma.

Product Categories/Family for anti-MAPK6 antibody

Death Receptor Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 4506091
• NCBI GeneID: 5597
• NCBI Accession #: NP_002739.1
• NCBI GenBank Nucleotide #: NM_002748.3
• UniProt Accession #: Q16659; Q68DH4; Q8IYN8
• Molecular Weight: 82,681 Da
• NCBI Official Full Name: mitogen-activated protein kinase 6
• NCBI Official Synonym Full Names: mitogen-activated protein kinase 6
• NCBI Official Symbol: MAPK6
• NCBI Official Synonym Symbols: ERK3; PRKM6; p97MAPK; HsT17250
• NCBI Protein Information: mitogen-activated protein kinase 6; ERK-3; MAPK 6; p97-MAPK; MAP kinase 6; MAP kinase isoform p97; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p9
• UniProt Protein Name: Mitogen-activated protein kinase 6
• UniProt Gene Name: MAPK6
• UniProt Synonym Gene Names: ERK3; PRKM6; MAP kinase 6; MAPK 6; ERK-3; p97-MAPK
• UniProt Entry Name: MK06_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]

Uniprot Description

ERK3: a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.

Protein type: Kinase, protein; Protein kinase, CMGC; EC 2.7.11.24; Protein kinase, Ser/Thr (non-receptor); CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: cytoplasm; nucleus

Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; protein heterodimerization activity; protein kinase binding; ATP binding

Biological Process: MAPKKK cascade; signal transduction; cell cycle; protein amino acid phosphorylation