Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Monocyte chemotactic protein 4 (MCP-4) Standard Curve.)
Human Monocyte Chemotactic Protein 4 (MCP-4) ELISA Kit | MCP-4 elisa kit
Human Monocyte Chemotactic Protein 4 (MCP-4) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Monocyte chemotactic protein 4 (MCP-4) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Monocyte chemotactic protein 4 (MCP-4) Standard Curve.)
Background: Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family.The chemokines are secreted proteins involved in immunoregulatory and inflammatory processes. Naruse et al. (1996) identified on chromosome 17q11.2 a cluster of chemokines from the CC family (characterized by a cys-cys sequence motif) and distinguished from a second chemokine family that features a cys-xxx-cys (CXC) motif. They mapped 1 gene of the CC family (called NCC1 by them) to the cluster using a panel of somatic cell hybrids with known deletions. NCC1 was originally characterized as an expressed sequence tag (EST). The deduced order of genes from a YAC contig assembled for the region is cen--NF1--MCP3, MCP1, NCC1, I-309--Y1741 breakpoint--RANTES--LD78-gamma, AT744.2, LD78-beta --NCC3, NCC2, AT744.1), LD78-alpha--NCC4--RARA --tel.
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
Uniprot Description
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space
Molecular Function: chemokine activity; receptor binding
Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; cytoskeleton organization and biogenesis; immune response; signal transduction; inflammatory response; chemotaxis
Research Articles on MCP-4
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Product Notes
The Human MCP-4 ccl13 (Catalog #AAA9716247) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716247 ELISA Kit recognizes Human MCP-4. It is sometimes possible for the material contained within the vial of "Monocyte Chemotactic Protein 4 (MCP-4), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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