Human MIP-3alpha ELISA Kit | MIP-3alpha elisa kit

MIP-3alpha (Human) OmniKine ELISA Kit

Cat. Num. AAA9501980

• Gene Names: CCL20; CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha
• Reactivity: Human
• Synonyms: MIP-3alpha; MIP-3alpha (Human) OmniKine ELISA Kit; C-C motif chemokine 20; Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; Small-inducible cytokine A20; MIP-3alpha elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human MIP-3alpha ELISA is capable of recognizing both recombinant and naturally produced Human MIP-3alpha proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: MCP-1, MIP-beta; Murine: JE/MCP-1, MIP-3alpha, MIP-3beta; Rat: MIP-3alpha
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 95

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human MIP-3alpha ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human MIP-3alpha proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 194239688
• NCBI GeneID: 6364
• NCBI Accession #: NP_001123518.1
• NCBI GenBank Nucleotide #: NM_001130046.1
• UniProt Accession #: P78556; Q53S51; Q99664
• Molecular Weight: 10,691 Da
• NCBI Official Full Name: C-C motif chemokine 20 isoform 2
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 20
• NCBI Official Symbol: CCL20
• NCBI Official Synonym Symbols: CKb4; LARC; ST38; MIP3A; Exodus; MIP-3a; SCYA20; MIP-3-alpha
• NCBI Protein Information: C-C motif chemokine 20
• UniProt Protein Name: C-C motif chemokine 20
• UniProt Gene Name: CCL20
• UniProt Synonym Gene Names: LARC; MIP3A; SCYA20; MIP-3-alpha

NCBI Description

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: CCR6 chemokine receptor binding; chemokine activity; protein binding

Biological Process: cell-cell signaling; chemotaxis; defense response to bacterium; G-protein coupled receptor signaling pathway; immune response; inflammatory response; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of interleukin-1 alpha biosynthetic process; positive regulation of nitric-oxide synthase biosynthetic process; signal transduction; wound healing