Testing Data
(Detection of ChREBP in 20ug of human hepatocyte lysate using MBS621105. 5-10 second film exposure.)
Rabbit WBSCR14 Polyclonal Antibody | anti-MLXIPL antibody
WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop-
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Immunofluorescence: 1:100-1:500
Immunohistochemistry: Formalin-fixed paraffin-embedded sections
Western Blot: 1:1000 detects a band at ~95kD
Testing Data
(Detection of ChREBP in 20ug of human hepatocyte lysate using MBS621105. 5-10 second film exposure.)
Testing Data
(Detection of ChREBP in 20ug of human hepatocyte lysate using MBS621105. 5-10 second film exposure.)
Immunofluorescence (IF)
(Immunofluorescent staining of a human hepatocyte using MBS621105. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).)
Immunofluorescence (IF)
(Immunofluorescent staining of a human hepatocyte using MBS621105. Overlay staining of ChREBP (rhodamine red) and DAPI nuclear staining (blue).)
Testing Data
(Colon, Epithelium 40X using MBS621105)
Testing Data
(Colon, Epithelium 40X using MBS621105)
Testing Data
(Detection of ChREBP in liver nuclear extracts from well-fed rats. 7% SDS gel, 1:1,000 dilution of MBS621105.)
Testing Data
(Detection of ChREBP in liver nuclear extracts from well-fed rats. 7% SDS gel, 1:1,000 dilution of MBS621105.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. [provided by RefSeq]
Uniprot Description
ChREBP: Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. Binds DNA as a heterodimer with TCFL4/MLX. Expressed in liver, heart, kidney, cerebellum and intestinal tissues. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus
Molecular Function: protein homodimerization activity; DNA binding; protein heterodimerization activity; transcription factor binding; transcription factor activity
Biological Process: positive regulation of fatty acid biosynthetic process; anatomical structure morphogenesis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of cellular metabolic process; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of lipid biosynthetic process; glucose homeostasis; glucose mediated signaling; regulation of transcription from RNA polymerase II promoter; regulation of fatty acid biosynthetic process; regulation of transcription, DNA-dependent; fatty acid homeostasis; positive regulation of glycolysis; positive regulation of cell proliferation; energy reserve metabolic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Disease: Williams-beuren Syndrome
Research Articles on MLXIPL
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Product Notes
The MLXIPL mlxipl (Catalog #AAA621105) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The WBSCR14 (Williams Beuren Syndrome Chromosome Region 14, Williams-Beuren Syndrome Chromosome Region 14 Protein, Carbohydrate Responsive Element Binding Protein, CHREBP, MIO, MLX Interacting Protein-like, MLXIPL, Mlx Interactor, MONDOB, WS Basic Helix-loop- reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's WBSCR14 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF). Suitable for use in Chromatin Immunoprecipitation, Immunofluorescence, Western Blot and Immunohistochemistry. Dilution: Immunofluorescence: 1:100-1:500 Immunohistochemistry: Formalin-fixed paraffin-embedded sections Western Blot: 1:1000 detects a band at ~95kD. Researchers should empirically determine the suitability of the MLXIPL mlxipl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "WBSCR14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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