Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Mediator of RNA polymerase II transcription subunit 13-like (MED13L) Standard Curve.)
Human Mediator Of RNA Polymerase II Transcription Subunit 13-Like (MED13L) ELISA Kit | MED13L elisa kit
Human Mediator Of RNA Polymerase II Transcription Subunit 13-Like (MED13L) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Mediator of RNA polymerase II transcription subunit 13-like (MED13L) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Mediator of RNA polymerase II transcription subunit 13-like (MED13L) Standard Curve.)
Background: Mediator of RNA polymerase II transcription subunit 13-like encoded by MED13L is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. Mediator of RNA polymerase II transcription subunit 13-like is involved in early development of the heart and brain. Defects in MED13L are a cause of transposition of the great arteries, dextro-looped (DTGA).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA).[provided by RefSeq, Jul 2010]
Uniprot Description
THRAP2: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. Defects in MED13L are a cause of transposition of the great arteries dextro-looped type 1 (DTGA1). A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients often have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the circulations in order to support life minimally, but surgical intervention is always required. A chromosomal aberration involving MED13L is found in a patient with transposition of the great arteries, dextro- looped and mental retardation. Translocation t(12;17)(q24.1;q21). Belongs to the Mediator complex subunit 13 family.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q24.21
Cellular Component: Srb-mediator complex
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter
Disease: Transposition Of The Great Arteries, Dextro-looped 1
Research Articles on MED13L
Similar Products
Product Notes
The Human MED13L med13l (Catalog #AAA9715332) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715332 ELISA Kit recognizes Human MED13L. It is sometimes possible for the material contained within the vial of "Mediator Of RNA Polymerase II Transcription Subunit 13-Like (MED13L), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
