Human Mediator of RNA polymerase II transcription subunit 1 (MED1) ELISA Kit | MED1 elisa kit
Human Mediator of RNA polymerase II transcription subunit 1 (MED1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
Uniprot Description
MED1: a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. Also is a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. May regulates p53-dependent apoptosis. Is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. Two splice-variant isoforms have been described.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 17q12
Cellular Component: nucleoplasm; membrane; nucleolus; Srb-mediator complex; nucleus; chromatin
Molecular Function: ligand-dependent nuclear receptor binding; peroxisome proliferator activated receptor binding; chromatin DNA binding; retinoic acid receptor binding; transcription coactivator activity; receptor activity; transcription factor binding; thyroid hormone receptor coactivator activity; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; vitamin D receptor binding; transcription cofactor activity; LBD domain binding; estrogen receptor binding; thyroid hormone receptor binding; chromatin binding; nuclear hormone receptor binding
Biological Process: lens development in camera-type eye; fat cell differentiation; lactation; erythrocyte development; embryonic placenta development; regulation of cell cycle; positive regulation of transcription, DNA-dependent; positive regulation of estrogen receptor signaling pathway; positive regulation of mammary gland epithelial cell proliferation; cell morphogenesis; enucleate erythrocyte development; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; androgen biosynthetic process; embryonic hindlimb morphogenesis; angiogenesis; positive regulation of keratinocyte differentiation; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; organ regeneration; regulation of transcription from RNA polymerase I promoter; positive regulation of protein import into nucleus, translocation; monocyte differentiation; embryonic hemopoiesis; thyroid hormone generation; liver development; mRNA transcription from RNA polymerase II promoter; keratinocyte differentiation; negative regulation of neuron differentiation; androgen receptor signaling pathway; embryonic heart tube development; gene expression; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of apoptosis
Research Articles on MED1
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Product Notes
The Human MED1 med1 (Catalog #AAA7200999) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7200999 ELISA Kit recognizes Human MED1. It is sometimes possible for the material contained within the vial of "Mediator of RNA polymerase II transcription subunit 1 (MED1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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