Human Mabthera ELISA Kit

BioSim anti-Rituximab (Mabthera) (Human) ELISA Kit

Cat. Num. AAA849158

• Reactivity: Human
• Synonyms: Mabthera; BioSim anti-Rituximab (Mabthera) (Human) ELISA Kit; Mabthera elisa kit

• Reactivity: Human
• Specificity: This kit is used for quantitative measurement of antibody against Rituximab

• Assay Type: Sandwich
• Samples: Human serum or plasma
• Detection Range: 62-500ng/ml
• Sensitivity: 30ng/ml
• Precision: Intra-Assay: CV<15%; Inter-Assay: CV<15% (CV (%)= SD/mean X 100)
• Recovery rate: 85 - 115% with normal human serum samples with known concentrations
• Cross Reactivity: Rituximab (Rituxan, Mabthera) infusion camouflages/masks the presence of antibody to rituximab (ATR) in serum/plasma samples. Therefore, blood sampling time is critical for detection of ATR.
• Detection Method: Absorbance: 450nm
• Features & Benefits: Easy, convenient, sensitive and time-saving method to measure the level of antibody against Rituximab in human serum and plasma. It is convenient to obtain blood sample just before the infusion or at least 2 weeks after the infusion of Rituximab (Rituxan, Mabthera)
• Preparation and Storage: Store at 4 degree C; Shelf life: ~12 months

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for Mabthera elisa kit

Rituximab (Mabthera) is a genetically engineered chimeric murine/human monoclonal antibody specific to CD20. CD20 is an approximately 35 KDa transmembrane phosphoprotein involved in the activation, proliferation, and differentiation of B-lymphocytes. It is absent in terminally differentiated plasma cells. The Fab domain of rituximab binds to the CD20 antigen on B-lymphocytes and the Fc domain recruits immune effector functions to induce apoptosis in B cells. It is used in treating leukemias and lymphomas, some autoimmune disorders, and organ transplant. However, some patients develop unwanted immunogenicity, which leads to production of anti-drug-antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. BioSimTM anti-Rituximab ELISA kit is designed to quantify/measure the antibody against Rituximab with high specificity and sensitivity in biological matrices.

Product Categories/Family for Mabthera elisa kit

ELISA Kits; ELISA Kits for Cancer Research; ELISA Kits (A-Z); ELISA Kits for Immunology Research; BioSim; ELISA Kits for Biosimilar Antibodies; Drug Metabolism; Disposition; Assay Kits; Cancer Research; Growth Factors; CDs; Cytokines; Growth Factors & Hor