Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Lysophosphatidic acid receptor 3 (LPAR3) Standard Curve.)
Human Lysophosphatidic Acid Receptor 3 (LPAR3) ELISA Kit | LPAR3 elisa kit
Human Lysophosphatidic Acid Receptor 3 (LPAR3) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Lysophosphatidic acid receptor 3 (LPAR3) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human Lysophosphatidic acid receptor 3 (LPAR3) Standard Curve.)
Background: LPA and the structurally related lysolipid mediator sphingosine 1-phosphate (S1P) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1) are S1P receptors; others (e.g., EDG2) are LPA receptors. EDG7 mediates responses to unsaturated LPA.Sequence analysis predicted that the 353-amino acid EDG7 protein shares approximately 54% and 49% amino acid identity with EDG2 and EDG4, respectively, and less than 40% identity with the S1P-specific receptors (e.g., EDG1). Northern blot analysis detected a 4.3-kb EDG7 transcript in heart, pancreas, prostate, and testis, with lower expression in lung, ovary, and some cancer cell lines. Western blot analysis showed that transfected cells express EDG7 as an approximately 35-kD protein.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins. [provided by RefSeq, Jul 2008]
Uniprot Description
EDG7: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: axon; integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity; phospholipid binding; G-protein alpha-subunit binding; lipid binding
Biological Process: synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); activation of MAPK activity; bleb formation; positive regulation of calcium ion transport; positive regulation of collateral sprouting
Research Articles on LPAR3
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Product Notes
The Human LPAR3 lpar3 (Catalog #AAA9715458) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9715458 ELISA Kit recognizes Human LPAR3. It is sometimes possible for the material contained within the vial of "Lysophosphatidic Acid Receptor 3 (LPAR3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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