Typical Testing Data/Standard Curve (for reference only)
Human IL-35 (Interleukin 35) ELISA Kit | IL-35 elisa kit
Human IL-35 (Interleukin 35) Pre-Coated ELISA Kit
Reactivity
Human
Applications
ELISA
Synonyms
IL-35 (Interleukin 35); Human IL-35 (Interleukin 35) Pre-Coated ELISA Kit; IL-35 elisa kit
Reactivity
Human
Applicable Applications for IL-35 elisa kit
ELISA (EIA)
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for IL-35 elisa kit
Background/Introduction: IL-35, acts as a potent anti-inflammatory cytokine, which has been shown to be required for the optimal suppressive activity of regulatory T-cell populations in both mice and man. This cytokine is a member of IL-12 family, and formed by pairing IL-12alpha (also known as p35) and Epstein-Barr virus-induced gene 3 (EBI3). IL-35 is produced primarily by CD4+Foxp3+Treg cells and required for the suppressive activity of regulatory T-cell populations. It is also produced by activated B cells, tolerogenic dendritic cells and to a lesser extent by activated endothelial cells, smooth muscle cells, and monocytes. Mechanistically, IL-35 signals in the target cells by binding to heterodimeric (gp130-IL-12Rbeta2) or homodimeric (gp130-gp130 or IL-12Rbeta2-IL-12Rbeta2) receptors to inhibit immunological responses. In contrast to other immunosuppressive cytokine, TGF-beta, IL-35 is not a constitutively expressed cytokine but rather a responsive cytokine induced by inflammatory stimuli. The loss of IL-35 expression reduces the in vivo suppressive capacity of Treg. However, little is known regarding the definitive mechanisms of IL-35 in autoimmune disease. Therefore we investigated the immunoregulatory role of IL-35 in patients with RA (Rheumatoid arthritis).
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Product Notes
The Human IL-35 (Catalog #AAA669202) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA669202 ELISA Kit recognizes Human IL-35. AAA Biotech's IL-35 (Interleukin 35) can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Researchers should empirically determine the suitability of the IL-35 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IL-35 (Interleukin 35), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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