Human IGFBP-3 ELISA Kit | IGFBP-3 elisa kit

IGFBP-3 (Human) OmniKine ELISA Kit

Cat. Num. AAA9502056

• Gene Names: IGFBP3; IBP3; BP-53
• Reactivity: Human
• Synonyms: IGFBP-3; IGFBP-3 (Human) OmniKine ELISA Kit; Insulin-like growth factor-binding protein 3; IGF-binding protein 3; IGFBP-3 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human IGFBP-3 ELISA is capable of recognizing both recombinant and naturally produced Human IGFBP-3 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: IGF-I R, IGFBP-1, IGFBP-2, IGFBP-4, IGFBP-5, IGFBP-6
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 291

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 125-8000 pg/ml
• Sensitivity: 125-8000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human IGFBP-3 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IGFBP-3 proteins within the range of 125-8000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 62243068
• NCBI GeneID: 3486
• NCBI Accession #: NP_000589.2
• NCBI GenBank Nucleotide #: NM_000598.4
• UniProt Accession #: P17936; Q2V509; Q6P1M6; Q9UCL4; A4D2F5; D3DVM0
• Molecular Weight: 32,223 Da
• NCBI Official Full Name: insulin-like growth factor-binding protein 3 isoform b
• NCBI Official Synonym Full Names: insulin like growth factor binding protein 3
• NCBI Official Symbol: IGFBP3
• NCBI Official Synonym Symbols: IBP3; BP-53
• NCBI Protein Information: insulin-like growth factor-binding protein 3
• UniProt Protein Name: Insulin-like growth factor-binding protein 3
• UniProt Gene Name: IGFBP3
• UniProt Synonym Gene Names: IBP3; IBP-3; IGF-binding protein 3; IGFBP-3

NCBI Description

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Protein type: Cell development/differentiation; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p12.3

Cellular Component: endoplasmic reticulum lumen; extracellular exosome; extracellular region; extracellular space; insulin-like growth factor binding protein complex; nucleus

Molecular Function: fibronectin binding; insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; metal ion binding; protein binding; protein tyrosine phosphatase activator activity

Biological Process: apoptosis; cellular protein metabolic process; negative regulation of cell proliferation; negative regulation of protein phosphorylation; negative regulation of signal transduction; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; osteoblast differentiation; positive regulation of apoptosis; positive regulation of catalytic activity; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of myoblast differentiation; post-translational protein modification; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell growth; regulation of glucose metabolic process; regulation of insulin-like growth factor receptor signaling pathway; type B pancreatic cell proliferation