Human Gastric inhibitory polypeptide receptor (GIPR) ELISA Kit | GIPR elisa kit
Human Gastric inhibitory polypeptide receptor (GIPR) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Uniprot Description
GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: gastric inhibitory peptide receptor activity; transmembrane receptor activity; peptide hormone binding
Biological Process: desensitization of G-protein coupled receptor protein signaling pathway; generation of precursor metabolites and energy; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; adenylate cyclase activation; response to glucose stimulus; positive regulation of insulin secretion; response to axon injury; response to calcium ion; endocrine pancreas development; response to nutrient
