Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
Rabbit anti-Human CASP8AP2 Polyclonal Antibody | anti-CASP8AP2 antibody
CASP8AP2 Antibody
Immunohistochemistry: 1:25-1:100
Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
Testing Data
(Gel: 6%SDS-PAGE Lysate: 40ug Hela cell Primary antibody: 1/250 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/20.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded Human brain tissue using at dilution 1/20.)
NCBI and Uniprot Product Information
NCBI Description
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008]
Uniprot Description
CASP8AP2: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Protein type: Apoptosis; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 6q15
Cellular Component: PML body; mitochondrion; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; death receptor binding; SUMO polymer binding; apoptotic protease activator activity; caspase activator activity; transcription corepressor activity
Biological Process: caspase activation; transcription, DNA-dependent; induction of apoptosis via death domain receptors; regulation of transcription, DNA-dependent; signal transduction; cell cycle
Research Articles on CASP8AP2
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Product Notes
The CASP8AP2 casp8ap2 (Catalog #AAA9408935) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CASP8AP2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CASP8AP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:200-1:1000 Immunohistochemistry: 1:25-1:100. Researchers should empirically determine the suitability of the CASP8AP2 casp8ap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CASP8AP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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