Typical Testing Data/Standard Curve (for reference only)
Human Fibroblast Growth Factor 18 (FGF18) ELISA Kit | FGF18 elisa kit
Human Fibroblast Growth Factor 18 (FGF18) ELISA Kit
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This assay employs the competitive inhibition enzyme immunoassay technique. A monoclonal antibody specific to FGF18 has been pre-coated onto a microplate. A competitive inhibition reaction is launched between biotin labeled FGF18 and unlabeled FGF18 (Standards or samples) with the pre-coated antibody specific to FGF18. After incubation the unbound conjugate is washed off. Next, avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. The amount of bound HRP conjugate is reverse proportional to the concentration of FGF18 in the sample. After addition of the substrate solution, the intensity of color developed is reverse proportional to the concentration of FGF18 in the sample.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
Uniprot Description
FGF18: Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Belongs to the heparin-binding growth factors family.
Protein type: Secreted, signal peptide; Secreted; Cytokine
Chromosomal Location of Human Ortholog: 5q34
Cellular Component: extracellular space; nucleolus; extracellular region
Molecular Function: growth factor activity; type 2 fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; nervous system development; regulation of endothelial cell proliferation; anatomical structure morphogenesis; intramembranous ossification; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; chondrocyte development; signal transduction; positive regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of MAP kinase activity; positive regulation of chondrocyte differentiation; cell-cell signaling; positive regulation of cell proliferation; insulin receptor signaling pathway; innate immune response; angiogenesis; lung development; endochondral ossification
Research Articles on FGF18
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Product Notes
The Human FGF18 fgf18 (Catalog #AAA2024710) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2024710 ELISA Kit recognizes Human FGF18. It is sometimes possible for the material contained within the vial of "Fibroblast Growth Factor 18 (FGF18), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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