Human FGF-19 ELISA Kit | FGF-19 elisa kit

FGF-19 (Human) OmniKine ELISA Kit

Cat. Num. AAA9501947

• Reactivity: Human
• Synonyms: FGF-19; FGF-19 (Human) OmniKine ELISA Kit; Fibroblast growth factor 19; FGF-19 elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human FGF-19 ELISA is capable of recognizing both recombinant and naturally produced Human FGF-19 proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: FGF-R1alpha, FGF-R1beta, FGF-R2alpha, FGF-R2beta, FGF-R3, FGF-R4, FGF-R5; Murine: FGF-15
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 216

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human FGF-19 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human FGF-19 proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4826726
• NCBI GeneID: 9965
• NCBI Accession #: NP_005108.1
• NCBI GenBank Nucleotide #: NM_005117.2
• UniProt Accession #: O95750
• Molecular Weight: 24,003 Da
• NCBI Official Full Name: fibroblast growth factor 19
• NCBI Official Synonym Full Names: fibroblast growth factor 19
• NCBI Official Symbol: FGF19
• NCBI Protein Information: fibroblast growth factor 19
• UniProt Protein Name: Fibroblast growth factor 19
• UniProt Gene Name: FGF19
• UniProt Synonym Gene Names: FGF-19

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF19: Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. Belongs to the heparin-binding growth factors family.

Protein type: Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular region; intracellular

Molecular Function: 1-phosphatidylinositol-3-kinase activity; fibroblast growth factor receptor binding; growth factor activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein binding; Ras guanyl-nucleotide exchange factor activity

Biological Process: fibroblast growth factor receptor signaling pathway; heart development; MAPK cascade; nervous system development; neural crest cell migration; phosphatidylinositol phosphorylation; phosphoinositide-mediated signaling; positive regulation of cell proliferation; positive regulation of glucose import; positive regulation of GTPase activity; positive regulation of JNK cascade; positive regulation of protein phosphorylation; regulation of phosphatidylinositol 3-kinase signaling