Testing Data
(The OmniKine Human TGFbeta-R2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TGFbeta-R2 proteins within the range of 16-1000 pg/ml.)
Human TGFbeta-R2 ELISA Kit | TGFBR2 elisa kit
TGFbeta-R2 (Human) OmniKine ELISA Kit
Human: LAP, Latent TGF-beta1, TGFbeta-R1, TGFbeta-R3, TGF-beta1, TGF-beta1.2, TGF-beta2, TGF-beta3
Murine: TGFbeta-R2/Fc Chimera
Testing Data
(The OmniKine Human TGFbeta-R2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TGFbeta-R2 proteins within the range of 16-1000 pg/ml.)
Testing Data
(The OmniKine Human TGFbeta-R2 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TGFbeta-R2 proteins within the range of 16-1000 pg/ml.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Uniprot Description
TGFBR2: a TKL kinase of the serine/threonine-protein kinase receptor (STKR) family. R1 and R2 TGF-beta receptors dimerize after binding TGF-beta at the cell surface. Binds to DAXX. Defects can cause esophageal cancer.
Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily
Chromosomal Location of Human Ortholog: 3p24.1
Cellular Component: caveola; cytosol; external side of plasma membrane; integral component of membrane; membrane raft; plasma membrane; receptor complex; transforming growth factor beta receptor complex
Molecular Function: ATP binding; glycosaminoglycan binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; protein binding; signal transducer, downstream of receptor, with serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type II; transforming growth factor beta-activated receptor activity; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding
Biological Process: activation of protein kinase activity; aging; apoptosis; atrioventricular valve morphogenesis; blood vessel development; brain development; branching involved in blood vessel morphogenesis; cardiac left ventricle morphogenesis; cell proliferation involved in endocardial cushion morphogenesis; common-partner SMAD protein phosphorylation; embryo implantation; embryonic cranial skeleton morphogenesis; embryonic hemopoiesis; endocardial cushion fusion; gastrulation; growth plate cartilage chondrocyte growth; gut development; heart development; heart looping; in utero embryonic development; inferior endocardial cushion morphogenesis; lens development in camera-type eye; membranous septum morphogenesis; myeloid dendritic cell differentiation; negative regulation of cardiac muscle cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; organ regeneration; outflow tract morphogenesis; outflow tract septum morphogenesis; palate development; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of B cell tolerance induction; positive regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of cell proliferation; positive regulation of epithelial cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; positive regulation of mesenchymal cell proliferation; positive regulation of NK T cell differentiation; positive regulation of reactive oxygen species metabolic process; positive regulation of skeletal muscle tissue regeneration; positive regulation of smooth muscle cell proliferation; positive regulation of T cell tolerance induction; positive regulation of tolerance induction to self antigen; protein amino acid phosphorylation; receptor-mediated endocytosis; regulation of cell proliferation; regulation of gene expression; response to drug; response to estrogen; response to glucose stimulus; response to hypoxia; response to mechanical stimulus; response to nutrient; response to steroid hormone; smoothened signaling pathway; superior endocardial cushion morphogenesis; transforming growth factor beta receptor signaling pathway; tricuspid valve morphogenesis; vasculogenesis; wound healing
Disease: Colorectal Cancer, Hereditary Nonpolyposis, Type 6; Esophageal Cancer; Loeys-dietz Syndrome 2
Research Articles on TGFBR2
Similar Products
Product Notes
The Human TGFBR2 tgfbr2 (Catalog #AAA9501991) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501991 ELISA Kit recognizes Human TGFBR2. It is sometimes possible for the material contained within the vial of "TGFbeta-R2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
