Human TFPI ELISA Kit | TFPI elisa kit

TFPI (Human) OmniKine ELISA Kit

Cat. Num. AAA9502077

• Gene Names: TFPI; EPI; TFI; LACI; TFPI1
• Reactivity: Human
• Synonyms: TFPI; TFPI (Human) OmniKine ELISA Kit; Tissue factor pathway inhibitor; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI; TFPI1; TFPI elisa kit

• Reactivity: Human
• Specificity: The OmniKine Human TFPI ELISA is capable of recognizing both recombinant and naturally produced Human TFPI proteins. The antigens listed below were tested at 50 ng/ml and did not exhibit significant cross reactivity or interference.; Human: Coagulation Factor VII, Coagulation Factor XI, Coagulation Factor XIV, TFPI-2, Vitronectin, Coagulation Factor II, HDL, LDL, VLDL; Murine: TFPI, TFPI-2
• Form/Format: 12 x 8-Well Microstrips
• Sequence Length: 251

• Samples: Plasma, serum, lysate
• Assay Type: Sandwich ELISA
• Detection Range: 16-1000 pg/ml
• Sensitivity: 16-1000 pg/ml
• Detection Method: Colorimetric 450 nm
• Subtype: None
• Preparation and Storage: Store at 4 degree C for 6 months.

Testing Data

(The OmniKine Human TFPI ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human TFPI proteins within the range of 16-1000 pg/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 73760409
• NCBI GeneID: 7035
• NCBI Accession #: NP_001027452.1
• NCBI GenBank Nucleotide #: NM_001032281.3
• UniProt Accession #: P10646; O95103; Q53TS4
• Molecular Weight: 28,653 Da
• NCBI Official Full Name: tissue factor pathway inhibitor isoform b
• NCBI Official Synonym Full Names: tissue factor pathway inhibitor
• NCBI Official Symbol: TFPI
• NCBI Official Synonym Symbols: EPI; TFI; LACI; TFPI1
• NCBI Protein Information: tissue factor pathway inhibitor
• UniProt Protein Name: Tissue factor pathway inhibitor
• Protein Family: Tissue factor pathway inhibitor
• UniProt Gene Name: TFPI
• UniProt Synonym Gene Names: LACI; TFPI1; TFPI; EPI; LACI

NCBI Description

This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]

Uniprot Description

TFPI: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Membrane protein, GPI anchor; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: caveola; cell surface; endoplasmic reticulum; extracellular region; extracellular space; plasma membrane

Molecular Function: endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity

Biological Process: blood coagulation; blood coagulation, extrinsic pathway; cellular response to interleukin-1; cellular response to steroid hormone stimulus; negative regulation of blood coagulation; negative regulation of endopeptidase activity; response to estradiol