Human F box like/WD repeat containing protein TBL1Y (TBL1Y) ELISA Kit | TBL1Y elisa kit
Human F box like/WD repeat containing protein TBL1Y (TBL1Y) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Uniprot Description
TBL1Y: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family.
Chromosomal Location of Human Ortholog: Yp11.2
Cellular Component: histone deacetylase complex
Molecular Function: transcription corepressor activity
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; histone deacetylation
Research Articles on TBL1Y
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Product Notes
The Human TBL1Y tbl1y (Catalog #AAA7218053) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7218053 ELISA Kit recognizes Human TBL1Y. It is sometimes possible for the material contained within the vial of "F box like/WD repeat containing protein TBL1Y (TBL1Y), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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