Mouse TBL1Y Monoclonal Antibody | anti-TBL1Y antibody

TBL1Y Monoclonal Antibody

Cat. Num. AAA9400157

• Gene Names: TBL1Y; TBL1
• Reactivity: Human, Mouse, Porcine, Rat, Dog
• Applications: Western Blot, Immunocytochemistry
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: TBL1Y; Monoclonal Antibody; TBL1Y Monoclonal Antibody; F-box-like/WD repeat-containing protein TBL1Y transducin beta-like 1 transducin beta-like protein 1Y transducin-beta-like protein 1; Y-linked; anti-TBL1Y antibody

• Host: Mouse
• Reactivity: Human, Mouse, Porcine, Rat, Dog
• Clonality: Monoclonal
• Isotype: IgG2b
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
• Sequence Length: 522

• Applicable Applications for anti-TBL1Y antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: Western blotting: 1:1000
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant full length protein (522aa) of human TBL1Y.
• Target Name: TBL1Y
• Preparation and Storage: store at -20 degree C

Testing Data

(1:1000 dilution of this antibody detected TBL1Y on 40ug of cell lysates)

Testing Data

(1:150 dilution from a previous lot detected TBL1Y in Hela)

Product Categories/Family for anti-TBL1Y antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 15150805
• NCBI GeneID: 90665
• NCBI Accession #: NP_150600.1
• NCBI GenBank Nucleotide #: NM_033284.1
• UniProt Accession #: Q9BQ87; A1L4B3
• Molecular Weight: 56,688 Da
• NCBI Official Full Name: F-box-like/WD repeat-containing protein TBL1Y
• NCBI Official Synonym Full Names: transducin (beta)-like 1, Y-linked
• NCBI Official Symbol: TBL1Y
• NCBI Official Synonym Symbols: TBL1
• NCBI Protein Information: F-box-like/WD repeat-containing protein TBL1Y
• UniProt Protein Name: F-box-like/WD repeat-containing protein TBL1Y
• Protein Family: F-box-like/WD repeat-containing protein
• UniProt Gene Name: TBL1Y
• UniProt Synonym Gene Names: TBL1
• UniProt Entry Name: TBL1Y_HUMAN

NCBI Description

The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This gene is highly similar to TBL1X gene in nucleotide sequence and protein sequence, but the TBL1X gene is located on chromosome X and this gene is on chromosome Y. This gene has three alternatively spliced transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

TBL1Y: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange. Belongs to the WD repeat EBI family.

Chromosomal Location of Human Ortholog: Yp11.2

Cellular Component: histone deacetylase complex

Molecular Function: transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; histone deacetylation