Human Deoxycytidine Kinase (DCK) ELISA Kit | DCK elisa kit

Human Deoxycytidine Kinase (DCK) ELISA Kit

Cat. Num. AAA3801382

• Reactivity: Human
• Synonyms: Deoxycytidine Kinase (DCK); Human Deoxycytidine Kinase (DCK) ELISA Kit; DCK elisa kit

• Reactivity: Human
• Sequence Length: 260

• Samples: Serum, plasma, cell culture supernate and other biological fluids
• Assay Type: Sandwich
• Detection Range: 10 U/L-160 U/L
• Sensitivity: 1 U/L
• CAS: 53-43-0

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for DCK elisa kit

Intended Use: The Stop Solution changes the color from blue to yellow and the intensity of the color is measured at 450 nm using a spectrophotometer. In order to measure the concentration ofDCKin the sample, This DCKELISA Kit includes a set of calibration standards. The calibration standards are assayed at the same time as the samples and allow the operator to produce a standard curve of Optical Density versusDCKconcentration. The concentration ofDCKin the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4503269
• NCBI GeneID: 1633
• NCBI GenBank Nucleotide #: NP_000779.1
• UniProt Accession #: P27707
• NCBI Official Full Name: deoxycytidine kinase
• NCBI Official Synonym Full Names: deoxycytidine kinase
• NCBI Official Symbol: DCK
• NCBI Protein Information: deoxycytidine kinase
• UniProt Protein Name: Deoxycytidine kinase
• Protein Family: Deoxycytidine kinase
• UniProt Gene Name: DCK
• UniProt Synonym Gene Names: dCK
• UniProt Entry Name: DCK_HUMAN

NCBI Description

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

Uniprot Description

DCK: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. Belongs to the DCK/DGK family.

Protein type: Kinase, other; Nucleotide Metabolism - purine; EC 2.7.1.74; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 4q13.3-q21.1

Cellular Component: cytosol; nucleus

Molecular Function: protein homodimerization activity; nucleoside kinase activity; deoxycytidine kinase activity; drug binding; ATP binding

Biological Process: pyrimidine base metabolic process; pyrimidine nucleotide metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; pyrimidine nucleoside salvage; phosphorylation; purine salvage; purine base metabolic process; deoxyribonucleoside monophosphate biosynthetic process