Human Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit | CYR61 elisa kit

Human Cysteine Rich Protein, Angiogenic Inducer 61 (CYR61) ELISA Kit

Cat. Num. AAA452751

• Gene Names: CYR61; CCN1; GIG1; IGFBP10
• Reactivity: Human
• Synonyms: Cysteine Rich Protein; Angiogenic Inducer 61 (CYR61); Human Cysteine Rich Protein; Angiogenic Inducer 61 (CYR61) ELISA Kit; CCN1; GIG1; IGFBP10; CCN family member 1; Insulin-like growth factor-binding protein 10; CYR61 elisa kit

• Reactivity: Human
• Sequence Length: 381

• Samples: Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 31.25-2000pg/mL
• Sensitivity: 13.4pg/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 31542331
• NCBI GeneID: 3491
• NCBI Accession #: NP_001545.2
• NCBI GenBank Nucleotide #: NM_001554.4
• UniProt Accession #: O00622; O14934; O43775; Q9BZL7
• Molecular Weight: 42,027 Da
• NCBI Official Full Name: protein CYR61
• NCBI Official Synonym Full Names: cysteine rich angiogenic inducer 61
• NCBI Official Symbol: CYR61
• NCBI Official Synonym Symbols: CCN1; GIG1; IGFBP10
• NCBI Protein Information: protein CYR61
• UniProt Protein Name: Protein CYR61
• Protein Family: Protein
• UniProt Gene Name: CYR61
• UniProt Synonym Gene Names: CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

NCBI Description

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

Uniprot Description

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.