Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human CGMP-dependent protein kinase 2 (PRKG2) Standard Curve.)
Human CGMP-Dependent Protein Kinase 2 (PRKG2) ELISA Kit | PRKG2 elisa kit
Human CGMP-Dependent Protein Kinase 2 (PRKG2) ELISA Kit
* Allow all reagents to warm to room temperature for at least 30 minutes before opening.
* Pre-rinse the pipet tip with reagent, use fresh pipet tips for each sample, standard and reagent to avoid contamination.
* Unused wells must be kept desiccated at 4 degree C in the sealed bag provided.
* Mix Thoroughly is very important for the result. It is recommended using low frequency oscillator or slight hand shaking every 10 minutes.
* It is recommended that all samples and standards be assayed in duplicate or triplicate.
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human CGMP-dependent protein kinase 2 (PRKG2) Standard Curve.)
Typical Testing Data/Standard Curve (for reference only)
(Fig.1. Human CGMP-dependent protein kinase 2 (PRKG2) Standard Curve.)
Background: Pfeifer et al. (1996) noted that there are 2 forms of cGMP-dependent protein kinase (cGK), types I and II, which are encoded by distinct genes. Smooth muscle, platelets, and cerebellum contain high concentrations of cGKI, whereas cGKII is highly concentrated in brain, lung, and intestinal mucosa. Orstavik et al. (1996) cloned a human cDNA encoding type II cGK by using the mouse type II cGK cDNA to probe a cerebellum cDNA library. The 762-amino acid human type II cGK protein is 96% identical to the mouse and rat type II cGK proteins. Human type II cGK is expressed as a 6-kb mRNA in prostate, small intestine, and colon and as a 4.4-kb mRNA in thymus and prostate.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein binds to and inhibits the activation of several receptor tyrosine kinases. The membrane-bound protein is a regulator of intestinal secretion, bone growth and renin secretion. Alternate splicing results in multiple transcript variants encoding distinct isoforms whose regulatory N-termini differ in length but whose C-terminal catalytic domains are identical. [provided by RefSeq, May 2018]
Uniprot Description
PKG2: an AGC kinase of the PKG family. Type II cGMP-dependent protein kinase is expressed at high levels in brain, lung and intestinal mucosa.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.12; Kinase, protein; Protein kinase, AGC; AGC group; PKG family
Chromosomal Location of Human Ortholog: 4q13.1-q21.1
Cellular Component: nuclear membrane; apical plasma membrane; cytosol
Molecular Function: protein homodimerization activity; cGMP-dependent protein kinase activity; cGMP binding; ATP binding; protein kinase activity
Biological Process: circadian regulation of gene expression; regulation of nitric-oxide synthase activity; signal transduction; blood coagulation; protein amino acid phosphorylation; nitric oxide metabolic process
Research Articles on PRKG2
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Product Notes
The Human PRKG2 prkg2 (Catalog #AAA9716004) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9716004 ELISA Kit recognizes Human PRKG2. It is sometimes possible for the material contained within the vial of "CGMP-Dependent Protein Kinase 2 (PRKG2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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