Human Cereblon (CRBN) ELISA Kit | CRBN elisa kit

Human Cereblon (CRBN) ELISA Kit

Cat. Num. AAA455591

• Gene Names: CRBN; MRT2; MRT2A
• Reactivity: Human
• Synonyms: Cereblon (CRBN); Human Cereblon (CRBN) ELISA Kit; MRT2A; Mental Retardation; Non-Syndromic; Autosomal Recessive 2A; CRBN elisa kit

• Reactivity: Human
• Sequence Length: 441

• Samples: Tissue homogenates, cell lysates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.125ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 291045198
• NCBI GeneID: 51185
• NCBI Accession #: NP_001166953.1
• NCBI GenBank Nucleotide #: NM_001173482.1
• UniProt Accession #: Q96SW2; Q6AI62; Q6NVZ0; Q9UHW4; B2R6H4; C9IZA9; C9JAH6
• Molecular Weight: 50,475 Da
• NCBI Official Full Name: protein cereblon isoform 2
• NCBI Official Synonym Full Names: cereblon
• NCBI Official Symbol: CRBN
• NCBI Official Synonym Symbols: MRT2; MRT2A
• NCBI Protein Information: protein cereblon
• UniProt Protein Name: Protein cereblon
• Protein Family: Protein cereblon
• UniProt Gene Name: CRBN

NCBI Description

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.