Human beta2-glycoprotein 1 antibody IgA/G/M (beta2-GP1 IgA/G/M) ELISA Kit | beta2-GP1 IgA/G/M elisa kit

Human beta2-glycoprotein 1 antibody IgA/G/M (beta2-GP1 IgA/G/M) ELISA Kit

Cat. Num. AAA2607962

• Gene Names: APOH; BG; B2G1; B2GP1
• Reactivity: Human
• Synonyms: beta2-glycoprotein 1 antibody IgA/G/M (beta2-GP1 IgA/G/M); Human beta2-glycoprotein 1 antibody IgA/G/M (beta2-GP1 IgA/G/M) ELISA Kit; Human beta2-glycoprotein 1 antibody IgA/G/M (b2-GP1 IgA/G/M) ELISA Kit; beta2-GP1 IgA/G/M elisa kit

• Reactivity: Human
• Sequence Length: 345

• Samples: Human serum, plasma, or cell culture supernatant
• Assay Type: Quantitative Sandwich
• Detection Range: 20 ng/mL-0.312 ng/mL
• Sensitivity: Up to 0.06 ng/mL
• Intra-assay Precision: <= 8%
• Inter-assay Precision: <= 12%
• Preparation and Storage: Store all reagents at 2-8 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for beta2-GP1 IgA/G/M elisa kit

Principle of the Assay: As mentioned above, this kit utilizes the Double Antigen Sandwich ELISA technique. The pre-coated antigen is a related-Human beta2-GP1 IgA/G/M antigen, while the detection antigen is another antigen. Samples are added into ELISA plate wells and washed out with PBS or TBS after their respective additions to the wells. Then Avidin-peroxidase conjugates are added to the wells in after. TMB substrate is used for coloration after the enzyme conjugate has already been thoroughly washed out of the wells by PBS or TBS. TMB reacts to form a blue product from the peroxidase activity, and finally turns to yellow after addition of the stop solution (Color Reagent C). The color intensity and quantity of target analyte in the sample are positively correlated.

NCBI and Uniprot Product Information

• NCBI GI #: 153266841
• NCBI GeneID: 350
• NCBI Accession #: NP_000033.2
• NCBI GenBank Nucleotide #: NM_000042.2
• Molecular Weight: 38,298 Da
• NCBI Official Full Name: beta-2-glycoprotein 1
• NCBI Official Synonym Full Names: apolipoprotein H
• NCBI Official Symbol: APOH
• NCBI Official Synonym Symbols: BG; B2G1; B2GP1
• NCBI Protein Information: beta-2-glycoprotein 1
• UniProt Protein Name: Beta-2-glycoprotein 1
• UniProt Gene Name: APOH
• UniProt Synonym Gene Names: B2G1; Apo-H; B2GPI; Beta(2)GPI
• UniProt Entry Name: APOH_HUMAN

NCBI Description

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Uniprot Description

APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cell surface; chylomicron; extracellular matrix; extracellular region; extracellular space

Molecular Function: glycoprotein binding; identical protein binding; lipid binding; phospholipid binding; protein binding

Biological Process: blood coagulation, intrinsic pathway; negative regulation of angiogenesis; negative regulation of blood coagulation; negative regulation of endothelial cell proliferation; negative regulation of fibrinolysis; negative regulation of myeloid cell apoptosis; plasminogen activation; platelet degranulation; positive regulation of blood coagulation; positive regulation of lipoprotein lipase activity; regulation of fibrinolysis; triacylglycerol metabolic process; triacylglycerol transport