Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA Kit | ADRbK1 elisa kit

Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA Kit

Cat. Num. AAA455420

• Gene Names: GRK2; BARK1; ADRBK1; BETA-ARK1
• Reactivity: Human
• Synonyms: Adrenergic Receptor Beta Kinase 1 (ADRbK1); Human Adrenergic Receptor Beta Kinase 1 (ADRbK1) ELISA Kit; B-ARK1; bARK1; Beta-ARK1; GRK2; G-protein coupled receptor kinase 2; ADRbK1 elisa kit

• Reactivity: Human
• Sequence Length: 689

• Samples: Serum, plasma, tissue homogenates and other biological fluids.
• Assay Type: Sandwich
• Detection Range: 0.312-20ng/mL
• Sensitivity: 0.105ng/mL
• Intra Assay: CV<10%
• Inter Assay: CV<12%
• Preparation and Storage: For unopened kit, all reagents should be kept according to the labels on vials. The TMB Substrate, Wash Buffer, Stop Solution should be stored at 4 degree C. All others should be stored at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 148539876
• NCBI GeneID: 156
• NCBI Accession #: NP_001610.2
• NCBI GenBank Nucleotide #: NM_001619.3
• UniProt Accession #: P25098; Q13837; Q6GTT3; B0ZBE1
• Molecular Weight: 79,574 Da
• NCBI Official Full Name: beta-adrenergic receptor kinase 1
• NCBI Official Synonym Full Names: G protein-coupled receptor kinase 2
• NCBI Official Symbol: GRK2
• NCBI Official Synonym Symbols: BARK1; ADRBK1; BETA-ARK1
• NCBI Protein Information: beta-adrenergic receptor kinase 1
• UniProt Protein Name: Beta-adrenergic receptor kinase 1
• UniProt Gene Name: GRK2
• UniProt Synonym Gene Names: Beta-ARK-1

NCBI Description

The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]

Uniprot Description

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.