Typical Testing Data/Standard Curve (for reference only)
Human 11-Dehydrothromboxane B2 ELISA Kit
11-Dehydrothromboxane B2 ELISA Kit
Reactivity
Human
Synonyms
11-Dehydrothromboxane B2; 11-Dehydrothromboxane B2 ELISA Kit; 11-Dehydrothromboxane B2 elisa kit
Reactivity
Human
Specificity
For in vitro quantitative determination of 11dhTxB2 in human urine samples. The kit can detect as low as 15.6pg/ml of 11dhTxB2 in 60 minutes.
Assay Type
Competitive
Detection Method
Absorbance at 412nM
Sample Type
Human Urine
Features & Benefits
A competitive ELISA based kit. A quick and reliable method
Preparation and Storage
Store at -20 degree C
Shipping: Gel Pack
Shelf Life: Est.~12 months
Shipping: Gel Pack
Shelf Life: Est.~12 months
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Related Product Information for 11-Dehydrothromboxane B2 elisa kit
11-Dehydrothromboxane B2 (11dhTxB2 or 11-dehydro-TxB2) is a stable metabolite of Thromboxane A2 (TxA2). TxA2 is a prothrombotic agent capable of promoting the activation and subsequent aggregation of platelets nearby. It is derived from Arachidonic Acid in the COX pathway and is involved in maintaining hemostasis & preventing cardiovascular diseases. TxA2 has a very short half-life and is quickly hydrolyzed to thromboxane B2 (TxB2), which further metabolizes to 11dhTxB2. 11dhTxB2 has a stable half-life and is excreted in the urine. It is unaffected by the ex vivo platelet activation and other pre-analytical variables. Urinary 11dhTxB2 can directly reflect the platelet production of TxA2 and represents a good and reliable biomarker for platelet activity. Additionally, Aspirin can irreversibly inhibit the platelet COX-1 activity thereby resulting in the inhibition of TxA2 production and thromboxane-mediated platelet activation. Thus, urine levels of 11dhTxB2 reflect COX-1 inhibition and can be used to monitor responses to Aspirin therapy. 11-Dehydrothromboxane B2 ELISA Kit can quickly and reliably determine a broad range of 11dhTxB2 concentrations in human urine samples. It is a competitive ELISA, based on the competition between the free 11dhTxB2 and 11dhTxB2-Acethylcholinesterase (AChE) conjugate for a constant amount of 11dhTxB2 monoclonal antibody binding sites. Thus, in the presence of an AChE substrate, the absorbance of the released product is inversely proportional to the amount of 11dhTxB2 in samples. The kit can detect as low as 15.6pg/ml of 11dhTxB2 in 60 minutes.
Product Categories/Family for 11-Dehydrothromboxane B2 elisa kit
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Product Notes
The Human 11-Dehydrothromboxane B2 (Catalog #AAA8400591) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8400591 ELISA Kit recognizes Human 11-Dehydrothromboxane B2. It is sometimes possible for the material contained within the vial of "11-Dehydrothromboxane B2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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