Human Parathyroid Hormone Related Protein (PTHrP) DIY ELISA Kit | PTHrP diy elisa kit
Human Parathyroid Hormone Related Protein (PTHrP) ELISA Kit DIY Materials
2. Aspirate and wash 1 time.
3. Block the plates with 200 muL per well of working solution of Blocking Buffer. Incubate at 37 degree C for 1.5 hours.
4. Aspirate and wash 1 time. The plates are now ready for sample detection, the protocol is the same as regular ELISA.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]
Uniprot Description
PTHrP: a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Three alternatively spliced isoforms have been described.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p11.22
Cellular Component: cytoplasm; extracellular region; extracellular space; Golgi apparatus; nucleoplasm
Molecular Function: peptide hormone receptor binding
Biological Process: cAMP metabolic process; cell-cell signaling; epidermis development; female pregnancy; G-protein signaling, adenylate cyclase activating pathway; negative regulation of cell proliferation; negative regulation of chondrocyte differentiation; osteoblast development; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; regulation of gene expression; skeletal development
Disease: Brachydactyly, Type E2
Research Articles on PTHrP
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Product Notes
The Human PTHrP pthlh (Catalog #AAA2088831) is a DIY ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2088831 DIY ELISA Kit recognizes Human PTHrP. Main materials for "Do It Yourself ELISA Kit". Researchers should empirically determine the suitability of the PTHrP pthlh for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Parathyroid Hormone Related Protein (PTHrP), DIY ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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