Adipokines: Adiponectin and CTRPs 1-7 Detection Set
Adipokines: Adiponectin and CTRPs 1-7 Detection Set
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
Antibodies are supplied as affinity chromatography purified IgG
Synonyms
Adipokines: Adiponectin and CTRPs 1-7; Adipokines: Adiponectin and CTRPs 1-7 Detection Set; Adipokines: Adiponectin and CTRPs 1-7 detection set
Reactivity
Human
Purity/Purification
Antibodies are supplied as affinity chromatography purified IgG
Form/Format
Liquid. PBS containing 0.02% sodium azide.
Concentration
Antibody 1mg/mL (varies by lot)
Applicable Applications for Adipokines: Adiponectin and CTRPs 1-7 detection set
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Immunogen
Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
Preparation and Storage
Stable at 4 degree C for three months, store at -20 degree C for up to one year.
Related Product Information for Adipokines: Adiponectin and CTRPs 1-7 detection set
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-A-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. Adiponectin is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene.
For images please see PDF data sheet
For images please see PDF data sheet
References
Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.
Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
Lihn AS, Pedersen SB, and Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes. Rev. 2005; 6:13-21.
Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
Lihn AS, Pedersen SB, and Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes. Rev. 2005; 6:13-21.
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Product Notes
The Adipokines: Adiponectin and CTRPs 1-7 (Catalog #AAA154733) is a Detection Set and is intended for research purposes only. The product is available for immediate purchase. The Adipokines: Adiponectin and CTRPs 1-7 Detection Set reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Adipokines: Adiponectin and CTRPs 1-7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the Adipokines: Adiponectin and CTRPs 1-7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Adipokines: Adiponectin and CTRPs 1-7, Detection Set" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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