Human Wingless Type MMTV Integration Site Family, Member 11 (WNT11) CLIA Kit | WNT11 clia kit

Human Wingless Type MMTV Integration Site Family, Member 11 (WNT11) CLIA Kit

Cat. Num. AAA2001130

• Gene Names: WNT11; HWNT11
• Reactivity: Human
• Synonyms: Wingless Type MMTV Integration Site Family; Member 11 (WNT11); Human Wingless Type MMTV Integration Site Family; Member 11 (WNT11) CLIA Kit; WNT11 clia kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of Wingless Type MMTV Integration Site Family, Member 11 (WNT11).; No significant cross-reactivity or interference between Wingless Type MMTV Integration Site Family, Member 11 (WNT11) and analogues was observed.
• Sequence Length: 354

• Assay Type: Double-antibody Sandwich
• Samples: Serum, Plasma, Tissue homogenates, Cell lysates, Cell culture supernates and Other Biological Fluids
• Detection Range: 13.7-10000pg/mL
• Sensitivity: < 4.9pg/mL
• Application: Chemiluminescent immunoassay for Antigen Detection.
• Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Wingless Type MMTV Integration Site Family, Member 11 (WNT11) were tested 20 times on one plate, respectively.
• Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Wingless Type MMTV Integration Site Family, Member 11 (WNT11) were tested on 3 different plates, 8 replicates in each plate.
• CV(%) =: SD/meanX100
• Intra-Assay: CV<10%
• Inter-Assay: CV<12%
• Preparation and Storage: The stability of kit is determined by the loss rate of activity. The loss rate of this kit is less than 5% within the expiration date under appropriate storage condition. ; To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for WNT11 clia kit

The microplate provided in this kit has been pre-coated with an antibody specific to Wingless Type MMTV Integration Site Family, Member 11 (WNT11). Standards or samples are then added to the appropriate microplate wells with a biotin-conjugated antibody specific to Wingless Type MMTV Integration Site Family, Member 11 (WNT11). Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then the mixture of substrate A and B is added to generate glow light emission kinetics. Upon plate development, the intensity of the emitted light is proportional to the Wingless Type MMTV Integration Site Family, Member 11 (WNT11) level in the sample or standard.;

Product Categories/Family for WNT11 clia kit

Signal transduction; Metabolic pathway; Bone metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 109735125
• NCBI GeneID: 7481
• UniProt Accession #: O96014; Q14DE8; Q8WZ98; B2R8Z6
• Molecular Weight: 39,179 Da
• NCBI Official Full Name: Wingless-type MMTV integration site family, member 11
• NCBI Official Synonym Full Names: wingless-type MMTV integration site family, member 11
• NCBI Official Symbol: WNT11
• NCBI Official Synonym Symbols: HWNT11
• NCBI Protein Information: protein Wnt-11
• UniProt Protein Name: Protein Wnt-11
• Protein Family: Protein
• UniProt Gene Name: WNT11
• UniProt Entry Name: WNT11_HUMAN

NCBI Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

Uniprot Description

WNT11: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: proteinaceous extracellular matrix; extracellular space; cytoplasm; extracellular region

Molecular Function: frizzled binding; protein kinase activator activity

Biological Process: response to nutrient levels; cell fate commitment; positive regulation of apoptosis; adrenal gland development; embryonic skeletal development; positive regulation of transcription, DNA-dependent; cloacal septation; palate development; Wnt receptor signaling pathway through beta-catenin; positive regulation of transforming growth factor-beta2 production; protein amino acid phosphorylation; bone mineralization; neuron differentiation; osteoblast differentiation; positive regulation of protein kinase activity; positive regulation of stress fiber formation; artery morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; negative regulation of cell migration; positive regulation of cell migration; negative regulation of apoptosis