Typical Testing Data/Standard Curve (for reference only)
Human FGFR1 (Fibroblast Growth Factor Receptor 1) CLIA Kit | FGFR1 clia kit
Human FGFR1 (Fibroblast Growth Factor Receptor 1) CLIA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to FGFR1. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for FGFR1 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain FGFR1, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of FGFR1. You can calculate the concentration of FGFR1 in the samples by comparing the RLU value of the samples to the standard curve.
NCBI and Uniprot Product Information
NCBI Description
proportion of transmembrane and soluble extracellular isoforms may modulate fibroblast growth factor signaling; plays a role in regulation of neuronal cell proliferation [RGD, Feb 2006]
Uniprot Description
FGFR1 iso2: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.
Protein type: Protein kinase, TK; Oncoprotein; EC 2.7.10.1; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; FGFR family
Cellular Component: cytoplasmic membrane-bound vesicle; integral to membrane; plasma membrane; nucleus; cytosol; receptor complex
Molecular Function: heparin binding; identical protein binding; protein binding; protein homodimerization activity; fibroblast growth factor binding; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; protein complex binding; cell adhesion molecule binding; glycoprotein binding; ATP binding
Biological Process: paraxial mesoderm development; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; orbitofrontal cortex development; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; induction of an organ; positive regulation of cell proliferation; salivary gland morphogenesis; positive regulation of mesenchymal cell proliferation; midbrain development; chondrocyte differentiation; negative regulation of osteoblast differentiation; angiogenesis; neurite development; central nervous system neuron development; positive regulation of cardiac muscle cell proliferation; embryonic limb morphogenesis; inner ear morphogenesis; motogenic signaling involved in postnatal olfactory bulb interneuron migration; fibroblast growth factor receptor signaling pathway; in utero embryonic development; outer ear morphogenesis; stem cell maintenance; positive regulation of cell cycle; regulation of cell proliferation; neuroblast division in the ventricular zone; mesenchymal cell differentiation; generation of neurons; regulation of gene expression; blood vessel morphogenesis; auditory receptor cell development; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; brain development; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification; lung development
Research Articles on FGFR1
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Product Notes
The Human FGFR1 fgfr1 (Catalog #AAA2533021) is a CLIA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2533021 CLIA Kit recognizes Human FGFR1. It is sometimes possible for the material contained within the vial of "FGFR1 (Fibroblast Growth Factor Receptor 1), CLIA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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