SDS-Page
PVRIG active protein
Recombinant Human PVRIG (C-mFc)
Gene Names
PVRIG; C7orf15
Purity
>95% as determined by reducing SDS-PAGE
Synonyms
PVRIG; Recombinant Human PVRIG (C-mFc); C7orf15; CD112R; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463; PVRIG active protein
Host
Human Cells
Purity/Purification
>95% as determined by reducing SDS-PAGE
Form/Format
Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
Sequence
Thr41-Asp171
Species
Human
Tag
C-mFc
Endotoxin
<1.0EU per ug as determined by the LAL method.
Protein Construction
Recombinant Human Transmembrane Protein PVRIG is produced by our Mammalian expression system and the target gene encoding Thr41-Asp171 is expressed with a mFc tag at the C-terminus.
Activity
1.Immobilized Human PVRIG-mFc at 10ug/ml (100ul/well) can bind Human Nectin-2-His .The ED50 of Human Nectin-2-His is 3.72 ug/ml.2.Immobilized Human PVRIG-mFc at 10ug/ml (100ul/well) can bind Biotinylated Human Nectin-2-His-Avi . The ED50 of Biotinylated Human Nectin-2-His-Avi is 0.42 ug/ml.
Preparation and Storage
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.
This product is provided as lyophilized powder which is shipped with ice packs.
This product is provided as lyophilized powder which is shipped with ice packs.
SDS-Page
SDS-Page
Related Product Information for PVRIG active protein
Human PVRIG (poliovirus receptor related immunoglobulin domain-containing protein), also known as CD112 receptor (CD112R), is an approximately 34kDa single transmembrane protein in the poliovirus receptor-like protein (PVR) family. The extracellular domain sequence of human and mouse PVRIG have approximately 65% similarity. PVRIG functions as a cell surface receptor for Nectin-2/CD112, a cell surface protein that is widely expressed on antigen-presenting cells and tumor cells. Disrupting the PVRIG/Nectin-2 interaction enhances human T cell response, suggesting PVRIG is a novel checkpoint for human T cells. PVRIG may act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.
Product Categories/Family for PVRIG active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
34,344 Da
NCBI Official Full Name
transmembrane protein PVRIG
NCBI Official Synonym Full Names
poliovirus receptor related immunoglobulin domain containing
NCBI Official Symbol
PVRIG
NCBI Official Synonym Symbols
C7orf15
NCBI Protein Information
transmembrane protein PVRIG; poliovirus receptor-related immunoglobulin domain-containing protein
UniProt Protein Name
Transmembrane protein PVRIG
Protein Family
UniProt Gene Name
PVRIG
UniProt Synonym Gene Names
C7orf15
UniProt Entry Name
PVRIG_HUMAN
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Product Notes
The PVRIG pvrig (Catalog #AAA2569202) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Thr41-Asp1 71. It is sometimes possible for the material contained within the vial of "PVRIG, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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