Discoidin Domain-Containing Receptor 2 Active Protein | Ddr1 active protein

Recombinant Mouse Discoidin Domain-Containing Receptor 2 Protein

Cat. Num. AAA2556749

• Gene Names: Ddr1; Cak; Nep; PTK3A; CD167a; AI323681; 6030432F18
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Discoidin Domain-Containing Receptor 2; Recombinant Mouse Discoidin Domain-Containing Receptor 2 Protein; Discoidin domain-containing receptor 2; Discoidin domain receptor 2; CD167 antigen-like family member B; Neurotrophic tyrosine kinase; receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD167b; Ddr2; Ddr1 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 911

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Leu444-Val874
• Fusion Tag: C-6His
• Activity: The specific activity was determined to be 2 nmol/min/mg using synthetic modified AXLtide peptide (modified-CKKSRGDYMTMQIG) as substrate.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

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Related Product Information for Ddr1 active protein

Protein Construction: Recombinant Mouse Discoidin domain-containing receptor 2 is produced by our Mammalian expression system and the target gene encoding Gln24-Arg399 is expressed with a 6His tag at the C-terminus.

Background: Discoidin domain receptor-2 (DDR2) is a cell surface tyrosine kinase receptor that can be activated by soluble collagen and has been implicated in diverse physiological functions including organism growth and wound repair. DDR2 binds to and is activated by collagen I, II, III, V, and X, with the notable exception of basement membrane collagen IV. DDR2 is expressed in connective tissues arising from embryonic mesoderm. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling.

NCBI and Uniprot Product Information

• NCBI GI #: 311771514
• NCBI GeneID: 12305
• NCBI Accession #: NP_001185760.1
• NCBI GenBank Nucleotide #: NM_001198831.1
• UniProt Accession #: Q03146
• Molecular Weight: Molecular Mass: 43.5kDa; Actual Protein Molecular Mass: 60-75kDa
• NCBI Official Full Name: epithelial discoidin domain-containing receptor 1 isoform 1
• NCBI Official Synonym Full Names: discoidin domain receptor family, member 1
• NCBI Official Symbol: Ddr1
• NCBI Official Synonym Symbols: Cak; Nep; PTK3A; CD167a; AI323681; 6030432F18
• NCBI Protein Information: epithelial discoidin domain-containing receptor 1
• UniProt Protein Name: Epithelial discoidin domain-containing receptor 1
• Protein Family: Discoidin domain-containing receptor
• UniProt Gene Name: Ddr1
• UniProt Synonym Gene Names: Cak; Eddr1; Mpk6; Epithelial discoidin domain receptor 1

Uniprot Description

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tumor cell invasion. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Phosphorylates PTPN11 (). Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing.