TMPRSS2 blocking peptide

TMPRSS2 Immunizing Peptide

Cat. Num. AAA425405

• Gene Names: TMPRSS2; PP9284; PRSS10
• Reactivity: Human
• Synonyms: TMPRSS2; TMPRSS2 Immunizing Peptide; transmembrane protease; serine 2; PRSS10; epitheliasin; TMPS2; TMPRSS2 blocking peptide

• Reactivity: Human
• Form/Format: 100ug of dried peptide
• Sequence: C-TDWIYRQMRADG
• Sequence Length: 492

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 14602459
• NCBI GeneID: 7113
• NCBI Accession #: NP_005647.2
• NCBI GenBank Nucleotide #: NM_005656.2
• Molecular Weight: 57,690 Da
• NCBI Official Full Name: transmembrane protease, serine 2
• NCBI Official Synonym Full Names: transmembrane protease, serine 2
• NCBI Official Symbol: TMPRSS2
• NCBI Official Synonym Symbols: PP9284; PRSS10
• NCBI Protein Information: transmembrane protease serine 2
• UniProt Protein Name: Transmembrane protease serine 2
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS2
• UniProt Synonym Gene Names: PRSS10
• UniProt Entry Name: TMPS2_HUMAN

NCBI Description

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

TMPRSS2: a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Protein type: EC 3.4.21.-; Membrane protein, integral; Protease

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; scavenger receptor activity; serine-type endopeptidase activity; serine-type peptidase activity

Biological Process: positive regulation of virion penetration into host cell; protein autoprocessing; proteolysis; receptor-mediated endocytosis