NANOG blocking peptide

NANOG Immunizing Peptide

Reactivity

Human

Synonyms

NANOG; NANOG Immunizing Peptide; Nanog homeobox; homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; NANOG (C Terminus); NANOG blocking peptide

Ordering
Cat. Num. AAA426162 When autocomplete results are available use up and down arrows to review and enter to select. Touch device users, explore by touch or with swipe gestures. For Research Use Only!

Reactivity

Human

Form/Format

100ug of dried peptide

Sequence

C-DLFLNYSMNMQPED

Sequence Length

305

Preparation and Storage

Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

NCBI GI #

153945816

NCBI GeneID

79923

NCBI Accession #

NP_079141.2

NCBI GenBank Nucleotide #

NM_024865.3

Molecular Weight

32,838 Da

NCBI Official Full Name

homeobox protein NANOG isoform 1

NCBI Official Synonym Full Names

Nanog homeobox

NCBI Official Symbol

NANOG

NCBI Protein Information

homeobox protein NANOG

UniProt Protein Name

Homeobox protein NANOG

Protein Family

NANOG neighbor homeobox

UniProt Gene Name

NANOG

UniProt Synonym Gene Names

hNanog

UniProt Entry Name

NANOG_HUMAN

NCBI Description

The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Uniprot Description

NANOG: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. Interacts with SMAD1 and SALL4. Expressed in testicular carcinoma and derived germ cell tumors. Expressed in fetal gonads, ovary and testis. Also expressed in ovary teratocarcinoma cell line and testicular embryonic carcinoma. Not expressed in many somatic organs and oocytes. Belongs to the Nanog homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

Biological Process: cell differentiation; cell proliferation; endodermal cell fate specification; positive regulation of transcription from RNA polymerase II promoter; regulation of cell differentiation; regulation of gene expression; regulation of transcription, DNA-dependent; somatic stem cell maintenance; stem cell maintenance; transcription, DNA-dependent

Research Articles on NANOG

1. Magnetofection-mediated NANOG delivery increased proliferation and enhanced the differentiation of hair follicle derived mesenchymal stem cells into smooth muscle cells.

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Product Notes

The NANOG nanog (Catalog #AAA426162) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The NANOG Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-DLFLNYSM NMQPED. It is sometimes possible for the material contained within the vial of "NANOG, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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