GIPR blocking peptide
GIPR Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011]
Uniprot Description
GIPR: This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2
Chromosomal Location of Human Ortholog: 19q13.3
Cellular Component: cytosol; integral to membrane; plasma membrane
Molecular Function: gastric inhibitory peptide receptor activity; peptide hormone binding; transmembrane receptor activity
Biological Process: adenylate cyclase activation; cell surface receptor linked signal transduction; desensitization of G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; endocrine pancreas development; generation of precursor metabolites and energy; positive regulation of insulin secretion; regulation of insulin secretion; response to axon injury; response to calcium ion; response to glucose stimulus; response to nutrient
Research Articles on GIPR
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Product Notes
The GIPR gipr (Catalog #AAA426480) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The GIPR Immunizing Peptide reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-EEQRQLPE RAFR. It is sometimes possible for the material contained within the vial of "GIPR, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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