APBA2 blocking peptide

APBA2 Peptide - N-terminal region

Cat. Num. AAA3244997

• Gene Names: APBA2; X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• Reactivity: Human
• Synonyms: APBA2; APBA2 Peptide - N-terminal region; APBA2 blocking peptide

• Reactivity: Human
• Form/Format: Lyophilized powder
• Sequence: Synthetic peptide located within the following region: PAPEEQECHNHSPDGDSSSDYVNNTSEEEDYDEGLPEEEEGITYYIRYCP
• Sequence Length: 749

• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for APBA2 blocking peptide

This is a synthetic peptide designed for use in combination with anti-APBA2 Antibody, made

Target Description: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for APBA2 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 22035550
• NCBI GeneID: 321
• NCBI Accession #: NP_005494
• NCBI GenBank Nucleotide #: NM_005503.3
• UniProt Accession #: Q99767
• Molecular Weight: 82kDa
• NCBI Official Full Name: amyloid-beta A4 protein-binding family A member 2 isoform a
• NCBI Official Synonym Full Names: amyloid beta precursor protein binding family A member 2
• NCBI Official Symbol: APBA2
• NCBI Official Synonym Symbols: X11L; MINT2; LIN-10; HsT16821; X11-BETA; D15S1518E; MGC:14091
• NCBI Protein Information: amyloid-beta A4 precursor protein-binding family A member 2
• UniProt Protein Name: Amyloid beta A4 precursor protein-binding family A member 2
• Protein Family: Amyloid beta A4 precursor protein-binding family
• UniProt Gene Name: APBA2
• UniProt Synonym Gene Names: MINT2; X11L; Mint-2
• UniProt Entry Name: APBA2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]

Uniprot Description

APBA2: Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. Part of a multimeric complex containing STXBP1 and syntaxin-1. Binds to the cytoplasmic domain of amyloid protein beta, and to the nuclear factor NF-kappa-B/p65 via its PDZ domain. Interacts with the N-terminal domain of APBA2BP. Brain.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q11-q12

Cellular Component: plasma membrane

Molecular Function: protein binding; beta-amyloid binding

Biological Process: nervous system development; synaptic transmission; protein transport; in utero embryonic development; regulation of gene expression; multicellular organism growth; locomotory behavior