anti-Human SLC22A5 Antibody | anti-SLC22A5 antibody

SLC22A5 Antibody

Cat. Num. AAA852679

• Gene Names: SLC22A5; CDSP; OCTN2
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: SLC22A5; SLC22A5 Antibody; Solute carrier family 22 member 5; Organic cation/carnitine transporter 2; High-affinity sodium-dependent carnitine cotransporter; anti-SLC22A5 antibody

• Reactivity: Human
• Specificity: SLC22A5 antibody detects endogenous levels of total SLC22A5 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 581

• Applicable Applications for anti-SLC22A5 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human SLC22A5.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from Rat Heart cells and Rat Muscle cells, using SLC22A5 antibody.)

Product Categories/Family for anti-SLC22A5 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Wu X., Biochem. Biophys. Res. Commun. 246:589-595(1998). Tamai I., J. Biol. Chem. 273:20378-20382(1998). Nezu J., Nat. Genet. 21:91-94(1999).

NCBI and Uniprot Product Information

• NCBI GI #: 815890826
• NCBI GeneID: 6584
• NCBI Accession #: NP_001295051.1
• NCBI GenBank Nucleotide #: NM_001308122.1
• UniProt Accession #: O76082; Q6ZQZ8; Q96EH6; A2Q0V1; B2R844; D3DQ87
• Molecular Weight: 65,327 Da
• NCBI Official Full Name: solute carrier family 22 member 5 isoform a
• NCBI Official Synonym Full Names: solute carrier family 22 member 5
• NCBI Official Symbol: SLC22A5
• NCBI Official Synonym Symbols: CDSP; OCTN2
• NCBI Protein Information: solute carrier family 22 member 5
• UniProt Protein Name: Solute carrier family 22 member 5
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A5
• UniProt Synonym Gene Names: OCTN2

NCBI Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.