anti-Human RHG22 Antibody | anti-RHG22 antibody

RHG22 Antibody

Cat. Num. AAA8509930

• Gene Names: ARHGAP22; RhoGAP2; RhoGap22
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: RHG22; RHG22 Antibody; Rho GTPase activating 2; Rho GTPase activating 22; RHOGAP2; anti-RHG22 antibody

• Reactivity: Human
• Specificity: RHG22 antibody detects endogenous levels of total RHG22 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 714

• Applicable Applications for anti-RHG22 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500~1:1000; ELISA: 1:40000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human RHG22.
• Preparation and Storage: Store at-20 degree C for 1 year.

Western Blot (WB)

(Western blot analysis of extracts from K562 cells, using RHG22 antibody.)

References

Richnau N., J. Biol. Chem. 276:35060-35070(2001). Ota T., Nat. Genet. 36:40-45(2004). The MGC Project Team; Genome Res. 14:2121-2127(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 365733566
• NCBI GeneID: 58504
• NCBI Accession #: NP_001242953.1
• NCBI GenBank Nucleotide #: NM_001256024.1
• UniProt Accession #: Q7Z5H3; O00152; Q6ZSB0; A0AVP7; A5YM75; B4DED8; B9EGA0; C9JDM2
• Molecular Weight: 77,457 Da
• NCBI Official Full Name: rho GTPase-activating protein 22 isoform 1
• NCBI Official Synonym Full Names: Rho GTPase activating protein 22
• NCBI Official Symbol: ARHGAP22
• NCBI Official Synonym Symbols: RhoGAP2; RhoGap22
• NCBI Protein Information: rho GTPase-activating protein 22
• UniProt Protein Name: Rho GTPase-activating protein 22
• UniProt Gene Name: ARHGAP22
• UniProt Synonym Gene Names: RHOGAP2

NCBI Description

This gene encodes a member of the GTPase activating protein family which activates a GTPase belonging to the RAS superfamily of small GTP-binding proteins. The encoded protein is insulin-responsive, is dependent on the kinase Akt and requires the Akt-dependent 14-3-3 binding protein which binds sequentially to two serine residues. The result of these interactions is regulation of cell motility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter ().